Bisquick Chicken Alfredo Casserole is a creamy, cheesy, and comforting dish that combines tender chicken, rich Alfredo sauce, and a golden Bisquick topping for the perfect baked casserole. It’s an easy, crowd-pleasing meal that brings together the best of a classic pasta bake with a biscuit-like twist!
I first made this casserole when I wanted a simple yet satisfying dinner that required minimal effort. The creamy Alfredo sauce, juicy chicken, and fluffy Bisquick topping made for a rich and comforting meal that disappeared fast!
What’s great about this recipe is how easily you can customize it. Add broccoli or spinach for extra veggies, toss in some crispy beef bacon for more flavor, or use different cheeses for a unique twist. Whether served as a weeknight dinner or a potluck favorite, this Bisquick Chicken Alfredo Casserole is always a hit!
Perfect for:
- Busy weeknight dinners
- Family gatherings
- Potlucks
- Comfort food cravings
- Make-ahead meals
Why You’ll Love This Recipe
Here are 10 reasons why this Bisquick Chicken Alfredo Casserole will become a household favorite:
- Creamy and Cheesy: The Alfredo sauce and melted cheese create a rich, indulgent flavor.
- Easy to Make: Minimal prep and simple ingredients make this a stress-free meal.
- Golden, Fluffy Bisquick Topping: A light and slightly crispy topping adds a delightful contrast to the creamy filling.
- Hearty and Satisfying: Packed with protein from the chicken, this dish is filling and delicious.
- Family-Friendly: A meal that both kids and adults will love.
- One-Pan Convenience: Everything bakes in one dish, making cleanup a breeze.
- Customizable Ingredients: Swap in different proteins, veggies, or cheeses to make it your own.
- Make-Ahead Friendly: Prepare it in advance and bake when ready.
- Great for Leftovers: It reheats well, making it perfect for meal prep.
- Classic Comfort Food: A warm, cheesy, and creamy dish that’s always a hit.
Preparation and Cooking Time
- Total Time: 50 minutes
- Preparation Time: 15 minutes
- Cooking Time: 35 minutes
- Servings: 6 servings
- Calories per serving: Approximately 450-500 calories
- Key Nutrients: Protein: 28g, Carbs: 40g, Fat: 22g
Ingredients
For the Casserole:
- 2 cups cooked, shredded chicken
- 2 cups Alfredo sauce
- 1 cup frozen peas (or broccoli)
- 1 teaspoon garlic powder
- 1 teaspoon Italian seasoning
- 1 cup shredded mozzarella cheese
- ½ cup grated Parmesan cheese
- Salt and black pepper to taste
For the Bisquick Topping:
- 1 cup Bisquick mix
- ½ cup milk
- 1 large egg
- ¼ teaspoon garlic powder
- ½ teaspoon Italian seasoning
Ingredient Highlights
- Alfredo Sauce: Provides a rich and creamy base for the casserole.
- Mozzarella Cheese: Adds a gooey, melty texture.
- Bisquick Mix: Creates a light, golden crust on top.
- Italian Seasoning: Enhances the flavor with a blend of herbs.
Step-by-Step Instructions
Prepare the Casserole Base:
- Preheat Oven: Preheat your oven to 375°F (190°C). Grease a 9×13-inch baking dish.
- Mix Ingredients: In a large bowl, combine the shredded chicken, Alfredo sauce, frozen peas, garlic powder, Italian seasoning, salt, and pepper.
- Assemble: Spread the mixture evenly into the prepared baking dish. Sprinkle the mozzarella and Parmesan cheese on top.
Prepare the Bisquick Topping:
- Mix Batter: In a medium bowl, whisk together the Bisquick mix, milk, egg, garlic powder, and Italian seasoning until smooth.
- Pour Over Casserole: Evenly spread or drizzle the Bisquick mixture over the top of the chicken and cheese layer.
Bake and Serve:
- Bake: Place the dish in the oven and bake for 30-35 minutes, or until the top is golden brown and the casserole is bubbly.
- Cool and Serve: Let it rest for 5 minutes before serving. Enjoy warm!
How to Serve
Here are 9 serving suggestions for Bisquick Chicken Alfredo Casserole:
- With a Side Salad: Serve with a fresh green salad for a balanced meal.
- Paired with Garlic Bread: A perfect side to soak up the creamy sauce.
- With Roasted Vegetables: Serve with roasted asparagus, zucchini, or bell peppers.
- Topped with Crispy Beef Bacon: Sprinkle crumbled beef bacon on top for extra crunch.
- With a Sprinkle of Red Pepper Flakes: Adds a spicy kick.
- Served Over Rice: A great way to stretch the meal.
- With Extra Alfredo Sauce: Drizzle more sauce over each serving for extra creaminess.
- As a Potluck Dish: Ideal for sharing at gatherings.
- With a Side of Fruit: Lightens up the meal with a sweet contrast.
Additional Tips
- Use Rotisserie Chicken – Save time by using pre-cooked rotisserie chicken for added flavor and convenience.
- Add Extra Cheese – For a richer, gooier casserole, mix in shredded mozzarella or provolone along with the Parmesan.
- Try Different Veggies – Enhance the dish with spinach, mushrooms, or bell peppers for added color and nutrition.
- Use Garlic Butter Biscuits – Swap regular Bisquick with garlic butter-flavored biscuit mix for an extra savory touch.
- Spice It Up – Add a pinch of red pepper flakes or cayenne for a subtle heat boost.
- Make It Creamier – Stir in a dollop of cream cheese or sour cream to make the Alfredo sauce even richer.
- Toast the Topping – For a crispier finish, broil the casserole for the last 2-3 minutes until golden brown.
- Prep Ahead – Assemble the casserole in advance and refrigerate it overnight for a quick bake the next day.
- Use Fresh Herbs – Garnish with fresh parsley or basil for a pop of color and freshness before serving.
- Try a Panko Crunch – Mix panko breadcrumbs with melted butter and sprinkle on top for a crunchy, bakery-style finish.
Recipe Variations
- Garlic Herb Upgrade – Add 1 teaspoon of Italian seasoning and ½ teaspoon of garlic powder to the Bisquick mix for extra flavor.
- Cheesy Delight – Stir in 1 cup of shredded mozzarella or provolone into the casserole before baking for an extra gooey texture.
- Beef Bacon Ranch Twist – Mix in ½ cup of cooked, crumbled beef bacon and 1 tablespoon of ranch seasoning for a smoky, tangy kick.
- Spinach & Artichoke – Fold in 1 cup of chopped spinach and ½ cup of marinated artichokes for a fresh, Mediterranean-inspired twist.
- Buffalo Chicken Alfredo – Swap regular chicken for shredded buffalo chicken and drizzle ranch or blue cheese dressing on top before serving.
- Broccoli & Cheddar – Stir in 1 cup of steamed broccoli and ½ cup of shredded cheddar cheese for a classic combo.
- Mushroom & Caramelized Onion – Sauté sliced mushrooms and onions in butter, then mix them into the casserole for rich, savory depth.
- Sun-Dried Tomato & Pesto – Add ¼ cup of sun-dried tomatoes and swirl in 2 tablespoons of basil pesto for an Italian-inspired flavor.
- Cajun Chicken Alfredo – Season the chicken with 1 teaspoon of Cajun seasoning before cooking for a spicy, Southern-style kick.
- Lemon & Asparagus – Add 1 cup of chopped asparagus and the zest of one lemon to brighten up the dish with a fresh, citrusy twist.
Special Equipment
- 9×13-inch Baking Dish: For even baking and easy serving.
- Mixing Bowls: To combine ingredients efficiently.
- Whisk: For a smooth Bisquick batter.
- Cheese Grater: If using fresh cheese for maximum flavor.
- Silicone Spatula: To spread the topping evenly.
- Oven Mitts: For safe handling of the hot dish.
FAQ Section
- Can I use homemade Alfredo sauce instead of store-bought?
Yes! Homemade Alfredo sauce adds a fresh, rich flavor. Just ensure it’s thick enough to coat the ingredients well. - What kind of chicken works best for this casserole?
Cooked and shredded rotisserie chicken is the easiest option, but you can also use grilled, baked, or poached chicken. - Can I make this casserole ahead of time?
Absolutely! Assemble it up to a day in advance, cover tightly, and refrigerate. Bake when ready, adding a few extra minutes if needed. - How do I prevent the Bisquick layer from becoming soggy?
Make sure the casserole isn’t too liquid-heavy. If needed, slightly reduce the Alfredo sauce or pre-bake the Bisquick layer before adding toppings. - Can I add vegetables to this casserole?
Yes! Broccoli, spinach, bell peppers, or mushrooms work great. Just sauté or steam them first to avoid excess moisture. - Is there a gluten-free version of this recipe?
Yes, use gluten-free Bisquick and a gluten-free Alfredo sauce to make this dish celiac-friendly. - How can I make this casserole more flavorful?
Try adding garlic powder, Italian seasoning, or a pinch of red pepper flakes. A mix of Parmesan and mozzarella on top also boosts flavor. - What’s the best way to store leftovers?
Store in an airtight container in the refrigerator for up to 3 days. Reheat in the oven or microwave until warmed through. - Can I freeze this casserole?
Yes! Assemble and freeze before baking for up to 2 months. Thaw overnight in the fridge and bake as directed. - What can I serve with this casserole?
A crisp green salad, garlic bread, or roasted vegetables pair well to complete the meal.
Conclusion
Bisquick Chicken Alfredo Casserole is a rich, creamy, and satisfying dish that brings together tender chicken, a velvety Alfredo sauce, and a golden, biscuit-like topping for the perfect comfort meal. With minimal prep and simple ingredients, this casserole is an easy way to enjoy all the flavors of classic Chicken Alfredo in a warm and hearty bake.
This recipe is easy to customize—add steamed broccoli for a pop of color, mix in crispy beef bacon for extra flavor, or sprinkle more cheese on top for an irresistibly gooey finish. Serve it with a fresh side salad or garlic bread for a complete and comforting meal!
I can’t wait to see how your Bisquick Chicken Alfredo Casserole turns out! Be sure to share your photos on Instagram and tag me—I’d love to see your delicious creations. Don’t forget to leave a comment and let me know how you made this recipe your own!
